Genotype

Internal Genotype ID 14294488
Symbol Vdac2
Name voltage-dependent anion channel 2
Type protein-coding
Organism Name Mus musculus
External ID MGI: MGI:106915
Alias Symbols Vdac6; mVDAC6; mVDAC2
Alias Names -
NCBI Gene ID 22334
Map Position Chromosome: 14
cM-Position: 11.91 cM
pq-Position: 14 A3
Sequences mRNA: NM_011695
Protein: AAC13321; AAH03731; BAE29617; BAE29717; BAE29975; BAE31090; BAE35185; BAE40159; BAE43231; EDL01463; NP_035825; Q60930
Genome: AC_000036; AC132590; AC151533; NC_000080; NT_039606; NW_001030542; U89988
Gene Ontology Molecular function: GO:0000166 nucleotide binding (IEA); GO:0005515 protein binding (IPI); GO:0008308 voltage-gated anion channel activity (IEA); GO:0015288 porin activity (IEA)
Biological process: GO:0006810 transport (IEA); GO:0006811 ion transport (IEA); GO:0006820 anion transport (IEA); GO:0032272 negative regulation of protein polymerization (IMP); GO:0044070 regulation of anion transport (IEA); GO:0055085 transmembrane transport (IEA); GO:2001243 negative regulation of intrinsic apoptotic signaling pathway (IMP)
Cellular component: GO:0005634 nucleus (ISO); GO:0005739 mitochondrion (IDA, ISO); GO:0005741 mitochondrial outer membrane (IEA); GO:0005743 mitochondrial inner membrane (IDA); GO:0016020 membrane (IEA); GO:0016021 integral component of membrane (IEA); GO:0042645 mitochondrial nucleoid (ISO); GO:0046930 pore complex (IEA); GO:0070062 extracellular vesicular exosome (ISO)
Orthologies
Gene conserved in Opisthokonta NCBI HomoloGene
Organism Symbol Name Sim type Identity NCBI Gene ID
Curated homology relationships: MGI:106915
Rattus norvegicus Vdac2 voltage-dependent anion channel 2 orthology 99.3 83531
Bos taurus VDAC2 voltage-dependent anion channel 2 orthology 97.2 282120
Macaca mulatta VDAC2 voltage-dependent anion channel 2 orthology 97.2 704257
Homo sapiens VDAC2 voltage-dependent anion channel 2 orthology 96.9 7417
Canis lupus familiaris VDAC2 voltage-dependent anion channel 2 orthology 96.9 479255
Pan troglodytes VDAC2 voltage-dependent anion channel 2 orthology 96.9 738876
Gallus gallus VDAC2 voltage-dependent anion channel 2 orthology 88.7 395498
Xenopus (Silurana) tropicalis vdac2 voltage-dependent anion channel 2 orthology 86.2 548947
Danio rerio vdac2 voltage-dependent anion channel 2 orthology 82.3 322126
Anopheles gambiae str. PEST AgaP_AGAP009833 AGAP009833-PA orthology 62.1 1279252
Drosophila melanogaster porin CG6647 gene product from transcript CG6647-RB homology 61.4 34500
Caenorhabditis elegans R05G6.7 Protein R05G6.7 orthology 42.4 177524
Neurospora crassa OR74A NCU04304 outer mitochondrial membrane protein porin homology 32.7 3877116
Magnaporthe oryzae 70-15 MGG_00968 mitochondrial outer membrane protein porin homology 32.1 2674473
Schizosaccharomyces pombe 972h- SPAC1635.01 mitochondrial outer membrane voltage-dependent anion-selective channel (predicted) orthology 31 2542750
Kluyveromyces lactis NRRL Y-1140 KLLA0F03553g hypothetical protein homology 30.8 2895262
Ashbya gossypii ATCC 10895 AGOS_ADL247C ADL247Cp homology 30.3 4619984
Saccharomyces cerevisiae S288c POR1 Por1p homology 27.8 855669
Description -
References
show all

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2. Huang Huiya et al., 2013-Jul-5
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake., J Biol Chem 288(27):19870-81 PubMed: 23720737

3. Kwon Woo-Sung et al., 2013-Feb
Voltage-dependent anion channels are a key factor of male fertility., Fertil Steril 99(2):354-61 PubMed: 23062735

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5. Min Choon Kee et al., 2012-Nov-1
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VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria., EMBO Rep 10(12):1341-7 PubMed: 19820692

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The VDAC2-BAK rheostat controls thymocyte survival., Sci Signal 2(85):ra48 PubMed: 19706873

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death., Nat Cell Biol 9(5):550-5 PubMed: 17417626

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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention., Proc Natl Acad Sci U S A 100(24):14109-14 PubMed: 14610273

30. Cheng Emily H Y et al., 2003-Jul-25
VDAC2 inhibits BAK activation and mitochondrial apoptosis., Science 301(5632):513-7 PubMed: 12881569

31. Stryke Doug et al., 2003-Jan-1
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34. Kawai J et al., 2001-Feb-8
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35. Hinsch K D et al., 2001-Apr-16
VDAC2 (porin-2) expression pattern and localization in the bovine testis., Biochim Biophys Acta 1518(3):329-33 PubMed: 11311949

36. Carninci P et al., 2000-Oct
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes., Genome Res 10(10):1617-30 PubMed: 11042159

37. Shibata K et al., 2000-Nov
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer., Genome Res 10(11):1757-71 PubMed: 11076861

38. Gwynn B et al., 2000-Dec-15
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39. Tanaka T S et al., 2000-Aug-1
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40. Carninci P; Hayashizaki Y, 1999
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41. Sampson M J et al., 1997-Jul-25
The murine voltage-dependent anion channel gene family. Conserved structure and function., J Biol Chem 272(30):18966-73 PubMed: 9228078

42. Sampson M J et al., 1996-Aug-15
A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8., Genomics 36(1):192-6 PubMed: 8812436

43. Sampson M J et al., 1996-Apr-15
Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms., Genomics 33(2):283-8 PubMed: 8660977