Internal Genotype ID 1277640
Symbol Vdac2
Name voltage-dependent anion channel 2
Type protein-coding
Organism Name Mus musculus
External ID RGD: 1552139
Alias Symbols mVDAC2; mVDAC6; Vdac6; VDAC-2; VDAC-6
Alias Names OTTMUSP00000017619; OTTMUSP00000017620; OTTMUSP00000053521; OTTMUSP00000053522; outer mitochondrial membrane protein porin 2; voltage-dependent anion-selective channel protein 2; voltage-dependent anion-selective channel protein 6
NCBI Gene ID 22334
Map Position Chromosome: 14
cM-Position: 11.91 cM
pq-Position: 14 A3
Sequences mRNA: AK012359; AK078555; AK150504; AK150627; AK150940; AK152274; AK159561; AK168199; AK168328; AK182774; AK191978; BC003731; BC049359; NM_011695; U30838
Protein: AAC13321; AAH03731; BAE29617; BAE29717; BAE29975; BAE31090; BAE35185; BAE40159; BAE43231; D3YUN8; D3YZT5; EDL01463; G3UX26; NP_035825; Q60930
Genome: AC_000036; AC132590; AC151533; NC_000080; NT_039606; NW_001030542; U89988
Gene Ontology Molecular function: GO:0000166 nucleotide binding (IEA); GO:0005515 protein binding (IPI); GO:0008308 voltage-gated anion channel activity (ISO); GO:0015288 porin activity (IEA)
Biological process: GO:0006810 transport (IEA); GO:0006811 ion transport (IEA); GO:0006820 anion transport (ISO); GO:0032272 negative regulation of protein polymerization (IMP); GO:0044070 regulation of anion transport (IEA); GO:0055085 transmembrane transport (IEA); GO:1903959 regulation of anion transmembrane transport (ISO); GO:2001243 negative regulation of intrinsic apoptotic signaling pathway (IMP)
Cellular component: GO:0005634 nucleus (ISO); GO:0005739 mitochondrion (IDA, ISO); GO:0005741 mitochondrial outer membrane (IEA); GO:0005743 mitochondrial inner membrane (IDA); GO:0008021 synaptic vesicle (ISO); GO:0016020 membrane (IEA); GO:0016021 integral component of membrane (IEA); GO:0042645 mitochondrial nucleoid (ISO); GO:0043209 myelin sheath (IDA); GO:0045121 membrane raft (ISO); GO:0046930 pore complex (IEA); GO:0070062 extracellular exosome (ISO)
Gene conserved in Opisthokonta NCBI HomoloGene
Organism Symbol Name Sim type Identity NCBI Gene ID
Curated homology relationships: MGI:106915
Rattus norvegicus Vdac2 voltage-dependent anion channel 2 orthology 99.3 83531
Bos taurus VDAC2 voltage-dependent anion channel 2 orthology 97.2 282120
Macaca mulatta VDAC2 voltage-dependent anion channel 2 orthology 97.2 704257
Pan troglodytes VDAC2 voltage-dependent anion channel 2 orthology 96.9 738876
Homo sapiens VDAC2 voltage-dependent anion channel 2 orthology 96.9 7417
Canis lupus familiaris VDAC2 voltage-dependent anion channel 2 orthology 96.9 479255
Gallus gallus VDAC2 voltage-dependent anion channel 2 orthology 88.7 395498
Xenopus (Silurana) tropicalis vdac2 voltage-dependent anion channel 2 orthology 86.2 548947
Danio rerio vdac2 voltage-dependent anion channel 2 orthology 82.3 322126
Anopheles gambiae str. PEST AgaP_AGAP009833 AGAP009833-PA orthology 62.1 1279252
Drosophila melanogaster porin CG6647 gene product from transcript CG6647-RB homology 61.4 34500
Caenorhabditis elegans vdac-1 Probable voltage-dependent anion-selective channel orthology 42.4 177524
Neurospora crassa OR74A por porin homology 32.7 3877116
Magnaporthe oryzae 70-15 MGG_00968 mitochondrial outer membrane protein porin homology 32.1 2674473
Schizosaccharomyces pombe 972h- SPAC1635.01 mitochondrial outer membrane voltage-dependent anion-selective channel (predicted) orthology 31 2542750
Kluyveromyces lactis NRRL Y-1140 KLLA0F03553g hypothetical protein homology 30.8 2895262
Eremothecium gossypii ATCC 10895 AGOS_ADL247C ADL247Cp homology 30.3 4619984
Saccharomyces cerevisiae S288c POR1 porin POR1 homology 27.8 855669

Summary: ENCODES a protein that exhibits voltage-gated anion channel activity (ortholog); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein polymerization; anion transport (ortholog); PARTICIPATES IN Huntington disease pathway; Parkinson disease pathway; ASSOCIATED WITH abnormal thymocyte apoptosis; decreased thymocyte number; small thymus; ASSOCIATED WITH Burns (ortholog); Epilepsy, Temporal Lobe (ortholog); Myocardial Infarction (ortholog); FOUND IN mitochondrial inner membrane; mitochondrion; myelin sheath; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; amiodarone

show all

1. Ma S B et al., 2014-Dec
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function., Cell Death Differ 21(12):1925-35 PubMed: 25146925

2. Cao Qi et al., 2014
The central role of EED in the orchestration of polycomb group complexes., Nat Commun 5:3127 PubMed: 24457600

3. Feng Yong-qiang et al., 2013-Mar-26
[Voltage dependent anion channel 2 involved mitochondrial apoptosis and its possible regulatory signal pathway in hearts of rats with severe scalds]., Zhonghua Yi Xue Za Zhi 93(12):939-43 PubMed: 23863682

4. Huang Huiya et al., 2013-Jul-5
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake., J Biol Chem 288(27):19870-81 PubMed: 23720737

5. Kwon Woo-Sung et al., 2013-Feb
Voltage-dependent anion channels are a key factor of male fertility., Fertil Steril 99(2):354-61 PubMed: 23062735

6. Piazzi Manuela et al., 2013-Aug
Phosphoinositide-specific phospholipase C ? 1b (PI-PLC?1b) interactome: affinity purification-mass spectrometry analysis of PI-PLC?1b with nuclear protein., Mol Cell Proteomics 12(8):2220-35 PubMed: 23665500

7. Min Choon Kee et al., 2012-Nov-1
Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca?+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart., Biochem J 447(3):371-9 PubMed: 22867515

8. Sang Liyun et al., 2011-May-13
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways., Cell 145(4):513-28 PubMed: 21565611

9. Skarnes William C et al., 2011-Jun-16
A conditional knockout resource for the genome-wide study of mouse gene function., Nature 474(7351):337-42 PubMed: 21677750

10. Diez-Roux Graciana et al., 2011
A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS Biol 9(1):e1000582 PubMed: 21267068

11. Bansal Arvin et al., 2010-Sep-10
Proteomic analysis reveals late exercise effects on cardiac remodeling following myocardial infarction., J Proteomics 73(10):2041-9 PubMed: 20601275

12. Roy Soumya Sinha et al., 2009-Dec
VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria., EMBO Rep 10(12):1341-7 PubMed: 19820692

13. Ren Decheng et al., 2009
The VDAC2-BAK rheostat controls thymocyte survival., Sci Signal 2(85):ra48 PubMed: 19706873

14. Hansen Gwenn M et al., 2008-Oct
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells., Genome Res 18(10):1670-9 PubMed: 18799693

15. McFarland Melinda A et al., 2008-Nov
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions., Mol Cell Proteomics 7(11):2123-37 PubMed: 18614564

16. De Marchi Umberto et al., 2008-Nov
A maxi-chloride channel in the inner membrane of mammalian mitochondria., Biochim Biophys Acta 1777(11):1438-48 PubMed: 18805391

17. Jones Steven P et al., 2008-Mar-4
Cardioprotection by N-acetylglucosamine linkage to cellular proteins., Circulation 117(9):1172-82 PubMed: 18285568

18. Pagliarini David J et al., 2008-Jul-11
A mitochondrial protein compendium elucidates complex I disease biology., Cell 134(1):112-23 PubMed: 18614015

19. Liu Xin-Yu et al., 2008-Feb
Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy., Proteomics 8(3):582-603 PubMed: 18186018

20. Hoffman Brad G et al., 2008
Identification of transcripts with enriched expression in the developing and adult pancreas., Genome Biol 9(6):R99 PubMed: 18554416

21. Jiang WenJing et al., 2007-Nov-1
Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics., J Neurosci Res 85(14):3160-70 PubMed: 17893921

22. Kaltenbach Linda S et al., 2007-May-11
Huntingtin interacting proteins are genetic modifiers of neurodegeneration., PLoS Genet 3(5):e82 PubMed: 17500595

23. Baines Christopher P et al., 2007-May
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death., Nat Cell Biol 9(5):550-5 PubMed: 17417626

24. Werner Hauke B et al., 2007-Jul-18
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin., J Neurosci 27(29):7717-30 PubMed: 17634366

25. Cui Xiang-Shun et al., 2007-Feb
Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation., Mol Reprod Dev 74(2):133-43 PubMed: 16998848

26. Bailey Peter J et al., 2006-Oct-1
A global genomic transcriptional code associated with CNS-expressed genes., Exp Cell Res 312(16):3108-19 PubMed: 16919269

27. Sabirov Ravshan Z et al., 2006-Jan-27
Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins., J Biol Chem 281(4):1897-904 PubMed: 16291750

28. Kim Sung Chan et al., 2006-Aug
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey., Mol Cell 23(4):607-18 PubMed: 16916647

29. Katayama S et al., 2005-Sep-2
Antisense transcription in the mammalian transcriptome., Science 309(5740):1564-6 PubMed: 16141073

30. Carninci P et al., 2005-Sep-2
The transcriptional landscape of the mammalian genome., Science 309(5740):1559-63 PubMed: 16141072

31. Visel Axel et al., 2004-Jan-1 an atlas of gene expression patterns in the mouse embryo., Nucleic Acids Res 32(Database issue):D552-6 PubMed: 14681479

32. Watahiki Akira et al., 2004-Dec
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas., Nat Methods 1(3):233-9 PubMed: 15782199

33. Da Cruz Sandrine et al., 2003-Oct-17
Proteomic analysis of the mouse liver mitochondrial inner membrane., J Biol Chem 278(42):41566-71 PubMed: 12865426

34. Mootha Vamsi K et al., 2003-Nov-26
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria., Cell 115(5):629-40 PubMed: 14651853

35. Zambrowicz Brian P et al., 2003-Nov-25
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention., Proc Natl Acad Sci U S A 100(24):14109-14 PubMed: 14610273

36. Cheng Emily H Y et al., 2003-Jul-25
VDAC2 inhibits BAK activation and mitochondrial apoptosis., Science 301(5632):513-7 PubMed: 12881569

37. Stryke Doug et al., 2003-Jan-1
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells., Nucleic Acids Res 31(1):278-81 PubMed: 12520002

38. Okazaki Y et al., 2002-Dec-5
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs., Nature 420(6915):563-73 PubMed: 12466851

39. Strausberg Robert L et al., 2002-Dec-24
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proc Natl Acad Sci U S A 99(26):16899-903 PubMed: 12477932

40. Kawai J et al., 2001-Feb-8
Functional annotation of a full-length mouse cDNA collection., Nature 409(6821):685-90 PubMed: 11217851

41. Hinsch K D et al., 2001-Apr-16
VDAC2 (porin-2) expression pattern and localization in the bovine testis., Biochim Biophys Acta 1518(3):329-33 PubMed: 11311949

42. Carninci P et al., 2000-Oct
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes., Genome Res 10(10):1617-30 PubMed: 11042159

43. Shibata K et al., 2000-Nov
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer., Genome Res 10(11):1757-71 PubMed: 11076861

44. Gwynn B et al., 2000-Dec-15
Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism., Blood 96(13):4227-35 PubMed: 11110696

45. Tanaka T S et al., 2000-Aug-1
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray., Proc Natl Acad Sci U S A 97(16):9127-32 PubMed: 10922068

46. Carninci P; Hayashizaki Y, 1999
High-efficiency full-length cDNA cloning., Methods Enzymol 303:19-44 PubMed: 10349636

47. Sampson M J et al., 1997-Jul-25
The murine voltage-dependent anion channel gene family. Conserved structure and function., J Biol Chem 272(30):18966-73 PubMed: 9228078

48. Sampson M J et al., 1996-Aug-15
A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8., Genomics 36(1):192-6 PubMed: 8812436

49. Sampson M J et al., 1996-Apr-15
Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms., Genomics 33(2):283-8 PubMed: 8660977