Genotype

Internal Genotype ID 1277640
Symbol Vdac2
Name voltage-dependent anion channel 2
Type protein-coding
Organism Name Mus musculus
External ID RGD: 1552139
Alias Symbols mVDAC2; mVDAC6; Vdac6; VDAC-2; VDAC-6
Alias Names OTTMUSP00000017619; OTTMUSP00000017620; OTTMUSP00000053521; OTTMUSP00000053522; outer mitochondrial membrane protein porin 2; voltage-dependent anion-selective channel protein 2; voltage-dependent anion-selective channel protein 6
NCBI Gene ID 22334
Map Position Chromosome: 14
cM-Position: 11.91 cM
pq-Position: 14 A3
Sequences mRNA: AK012359; AK078555; AK150504; AK150627; AK150940; AK152274; AK159561; AK168199; AK168328; AK182774; AK191978; BC003731; BC049359; NM_011695; U30838
Protein: AAC13321; AAH03731; BAE29617; BAE29717; BAE29975; BAE31090; BAE35185; BAE40159; BAE43231; D3YUN8; D3YZT5; EDL01463; G3UX26; NP_035825; Q60930
Genome: AC_000036; AC132590; AC151533; NC_000080; NT_039606; NW_001030542; U89988
Gene Ontology Molecular function: GO:0000166 nucleotide binding (IEA); GO:0005515 protein binding (IPI); GO:0008308 voltage-gated anion channel activity (ISO); GO:0015288 porin activity (IEA)
Biological process: GO:0006810 transport (IEA); GO:0006811 ion transport (IEA); GO:0006820 anion transport (ISO); GO:0032272 negative regulation of protein polymerization (IMP); GO:0044070 regulation of anion transport (IEA); GO:0055085 transmembrane transport (IEA); GO:1903959 regulation of anion transmembrane transport (ISO); GO:2001243 negative regulation of intrinsic apoptotic signaling pathway (IMP)
Cellular component: GO:0005634 nucleus (ISO); GO:0005739 mitochondrion (IDA, ISO); GO:0005741 mitochondrial outer membrane (IEA); GO:0005743 mitochondrial inner membrane (IDA); GO:0008021 synaptic vesicle (ISO); GO:0016020 membrane (IEA); GO:0016021 integral component of membrane (IEA); GO:0042645 mitochondrial nucleoid (ISO); GO:0043209 myelin sheath (IDA); GO:0045121 membrane raft (ISO); GO:0046930 pore complex (IEA); GO:0070062 extracellular exosome (ISO)
Orthologies
Gene conserved in Opisthokonta NCBI HomoloGene
Organism Symbol Name Sim type Identity NCBI Gene ID
Curated homology relationships: MGI:106915
Rattus norvegicus Vdac2 voltage-dependent anion channel 2 orthology 99.3 83531
Bos taurus VDAC2 voltage-dependent anion channel 2 orthology 97.2 282120
Macaca mulatta VDAC2 voltage-dependent anion channel 2 orthology 97.2 704257
Pan troglodytes VDAC2 voltage-dependent anion channel 2 orthology 96.9 738876
Homo sapiens VDAC2 voltage-dependent anion channel 2 orthology 96.9 7417
Canis lupus familiaris VDAC2 voltage-dependent anion channel 2 orthology 96.9 479255
Gallus gallus VDAC2 voltage-dependent anion channel 2 orthology 88.7 395498
Xenopus (Silurana) tropicalis vdac2 voltage-dependent anion channel 2 orthology 86.2 548947
Danio rerio vdac2 voltage-dependent anion channel 2 orthology 82.3 322126
Anopheles gambiae str. PEST AgaP_AGAP009833 AGAP009833-PA orthology 62.1 1279252
Drosophila melanogaster porin CG6647 gene product from transcript CG6647-RB homology 61.4 34500
Caenorhabditis elegans vdac-1 Probable voltage-dependent anion-selective channel orthology 42.4 177524
Neurospora crassa OR74A por porin homology 32.7 3877116
Magnaporthe oryzae 70-15 MGG_00968 mitochondrial outer membrane protein porin homology 32.1 2674473
Schizosaccharomyces pombe 972h- SPAC1635.01 mitochondrial outer membrane voltage-dependent anion-selective channel (predicted) orthology 31 2542750
Kluyveromyces lactis NRRL Y-1140 KLLA0F03553g hypothetical protein homology 30.8 2895262
Eremothecium gossypii ATCC 10895 AGOS_ADL247C ADL247Cp homology 30.3 4619984
Saccharomyces cerevisiae S288c POR1 porin POR1 homology 27.8 855669
Description

Summary: ENCODES a protein that exhibits voltage-gated anion channel activity (ortholog); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein polymerization; anion transport (ortholog); PARTICIPATES IN Huntington disease pathway; Parkinson disease pathway; ASSOCIATED WITH abnormal thymocyte apoptosis; decreased thymocyte number; small thymus; ASSOCIATED WITH Burns (ortholog); Epilepsy, Temporal Lobe (ortholog); Myocardial Infarction (ortholog); FOUND IN mitochondrial inner membrane; mitochondrion; myelin sheath; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; amiodarone

References
show all

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An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake., J Biol Chem 288(27):19870-81 PubMed: 23720737

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VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria., EMBO Rep 10(12):1341-7 PubMed: 19820692

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The VDAC2-BAK rheostat controls thymocyte survival., Sci Signal 2(85):ra48 PubMed: 19706873

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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey., Mol Cell 23(4):607-18 PubMed: 16916647

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32. Watahiki Akira et al., 2004-Dec
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas., Nat Methods 1(3):233-9 PubMed: 15782199

33. Da Cruz Sandrine et al., 2003-Oct-17
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36. Cheng Emily H Y et al., 2003-Jul-25
VDAC2 inhibits BAK activation and mitochondrial apoptosis., Science 301(5632):513-7 PubMed: 12881569

37. Stryke Doug et al., 2003-Jan-1
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40. Kawai J et al., 2001-Feb-8
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41. Hinsch K D et al., 2001-Apr-16
VDAC2 (porin-2) expression pattern and localization in the bovine testis., Biochim Biophys Acta 1518(3):329-33 PubMed: 11311949

42. Carninci P et al., 2000-Oct
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47. Sampson M J et al., 1997-Jul-25
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48. Sampson M J et al., 1996-Aug-15
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49. Sampson M J et al., 1996-Apr-15
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